Ontology-based gene network construction and interpretation of function interactions and disease phenotypes
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NetCrafter is an intuitive, user-friendly tool for creating gene networks and performing ontology clustering. Users can easily generate gene networks by providing a gene list - without requiring additional gene-gene relationship data. NetCrafter leverages ontologies such as Gene Ontology (GO) and Human Phenotype Ontology (HPO) to construct network structures specific to the input gene set. |
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Creating ontology-based gene networks
The figure illustrates the process of generating networks using Gene Ontology Biological Process (GOBP) terms and Human Phenotype Ontology (HPO)
terms containing 3 to 300 genes.
For a gene list, the -log(p-value) of each ontology term was calculated using Fisher's exact test. Tw(G1, G2) denotes the p-value weighted Tanimoto score.
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Ontolgoy clustering
Input ontology terms were clustered using the regular Tanimoto index between terms, ??(??1,??2), which measures the overlap in shared genes.
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