Oncogenic signatures (189)

Gene set Name Definition Number of genes
AKT_UP.V1_DNGenes down-regulated in mouse prostate by transgenic expression of human AKT1 gene vs controls. 187
AKT_UP.V1_UPGenes up-regulated in mouse prostate by transgenic expression of human AKT1 gene vs controls. 169
AKT_UP_MTOR_DN.V1_DNGenes down-regulated by everolimus in mouse prostate tissue transgenically expressing human AKT1 gene vs untreated controls. 185
AKT_UP_MTOR_DN.V1_UPGenes up-regulated by everolimus in mouse prostate tissue transgenically expressing human AKT1 gene vs untreated controls. 178
ALK_DN.V1_DNGenes down-regulated in DAOY cells (medulloblastoma) upon knockdown of ALK gene by RNAi. 139
ALK_DN.V1_UPGenes up-regulated in DAOY cells (medulloblastoma) upon knockdown of ALK gene by RNAi. 140
ATF2_S_UP.V1_DNGenes down-regulated in myometrial cells over-expressing a shortened splice form of ATF2 gene. 185
ATF2_S_UP.V1_UPGenes up-regulated in myometrial cells over-expressing a shortened splice form of ATF2 gene. 191
ATF2_UP.V1_DNGenes down-regulated in myometrial cells over-expressing ATF2 gene. 184
ATF2_UP.V1_UPGenes up-regulated in myometrial cells over-expressing ATF2 gene. 189
ATM_DN.V1_DNGenes down-regulated in HEK293 cells (kidney fibroblasts) upon knockdown of ATM gene by RNAi. 146
ATM_DN.V1_UPGenes up-regulated in HEK293 cells (kidney fibroblasts) upon knockdown of ATM gene by RNAi. 146
BCAT.100_UP.V1_DNGenes down-regulated in HEK293 cells (kidney fibroblasts) expressing constitutively active form of CTNNB1 gene. 39
BCAT.100_UP.V1_UPGenes up-regulated in HEK293 cells (kidney fibroblasts) expressing constitutively active form of CTNNB1 gene. 49
BCAT_BILD_ET_AL_DNGenes down-regulated in primary epithelial breast cancer cell culture over-expressing activated CTNNB1 gene. 46
BCAT_BILD_ET_AL_UPGenes up-regulated in primary epithelial breast cancer cell culture over-expressing activated CTNNB1 gene. 45
BMI1_DN.V1_DNGenes down-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 gene by RNAi. 138
BMI1_DN.V1_UPGenes up-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 gene by RNAi. 147
BMI1_DN_MEL18_DN.V1_DNGenes down-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 and PCGF2 genes by RNAi. 146
BMI1_DN_MEL18_DN.V1_UPGenes up-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 and PCGF2 genes by RNAi. 143
BRCA1_DN.V1_DNGenes down-regulated in MCF10A cells (breast cancer) upon knockdown of BRCA1 gene by RNAi. 139
BRCA1_DN.V1_UPGenes up-regulated in MCF10A cells (breast cancer) upon knockdown of BRCA1 gene by RNAi. 133
CAHOY_ASTROCYTICGenes up-regulated in astrocytes. 100
CAHOY_ASTROGLIALGenes up-regulated in astrogia cells. 99
CAHOY_NEURONALGenes up-regulated in neurons. 100
CAHOY_OLIGODENDROCUTICGenes up-regulated in oligodendrocytes. 100
CAMP_UP.V1_DNGenes down-regulated in primary thyrocyte cultures in response to cAMP signaling pathway activation by thyrotropin (TSH). 198
CAMP_UP.V1_UPGenes up-regulated in primary thyrocyte cultures in response to cAMP signaling pathway activation by thyrotropin (TSH). 199
CORDENONSI_YAP_CONSERVED_SIGNATUREYAP conserved signature. 57
CRX_DN.V1_DNGenes down-regulated in retina cells from CRX knockout mice. 130
CRX_DN.V1_UPGenes up-regulated in retina cells from CRX knockout mice. 135
CRX_NRL_DN.V1_DNGenes down-regulated in retina cells from CRX and NRL double knockout mice. 125
CRX_NRL_DN.V1_UPGenes up-regulated in retina cells from CRX and NRL double knockout mice. 139
CSR_EARLY_UP.V1_DNGenes down-regulated in early serum response of CRL 2091 cells (foreskin fibroblasts). 126
CSR_EARLY_UP.V1_UPGenes up-regulated in early serum response of CRL 2091 cells (foreskin fibroblasts). 153
CSR_LATE_UP.V1_DNGenes down-regulated in late serum response of CRL 2091 cells (foreskin fibroblasts). 146
CSR_LATE_UP.V1_UPGenes up-regulated in late serum response of CRL 2091 cells (foreskin fibroblasts). 165
CTIP_DN.V1_DNGenes down-regulated in MCF10A cells (breast cancer) upon knockdown of RBBP8 gene by RNAi. 134
CTIP_DN.V1_UPGenes up-regulated in MCF10A cells (breast cancer) upon knockdown of RBBP8 gene by RNAi. 133
CYCLIN_D1_KE_.V1_DNGenes down-regulated in MCF-7 cells (breast cancer) over-expressing a mutant K112E form of CCND1 gene. 189
CYCLIN_D1_KE_.V1_UPGenes up-regulated in MCF-7 cells (breast cancer) over-expressing a mutant K112E form of CCND1 gene. 187
CYCLIN_D1_UP.V1_DNGenes down-regulated in MCF-7 cells (breast cancer) over-expressing CCND1 gene. 188
CYCLIN_D1_UP.V1_UPGenes up-regulated in MCF-7 cells (breast cancer) over-expressing CCND1 gene. 186
DCA_UP.V1_DNGenes down-regulated in A549 lung carcinoma and M059K glioblastoma cells treated with dichloroacetate . 184
DCA_UP.V1_UPGenes up-regulated in A549 lung carcinoma and M059K glioblastoma cells treated with dichloroacetate . 186
E2F1_UP.V1_DNGenes down-regulated in mouse fibroblasts over-expressing E2F1 gene. 187
E2F1_UP.V1_UPGenes up-regulated in mouse fibroblasts over-expressing E2F1 gene. 187
E2F3_UP.V1_DNGenes down-regulated in primary epithelial breast cancer cell culture over-expressing E2F3 gene. 159
E2F3_UP.V1_UPGenes up-regulated in primary epithelial breast cancer cell culture over-expressing E2F3 gene. 189
EGFR_UP.V1_DNGenes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 and engineered to express ligand-activatable EGFR . 195
EGFR_UP.V1_UPGenes up-regulated in MCF-7 cells (breast cancer) positive for ESR1 and engineered to express ligand-activatable EGFR . 191
EIF4E_DNGenes down-regulated in HMEC cells (primary mammary epithelium) upon over-expression of EIF4E gene. 98
EIF4E_UPGenes up-regulated in HMEC cells (primary mammary epithelium) upon over-expression of EIF4E gene. 99
ERBB2_UP.V1_DNGenes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 and engineered to express ligand-activatable ERBB2 . 195
ERBB2_UP.V1_UPGenes up-regulated in MCF-7 cells (breast cancer) positive for ESR1 and engineered to express ligand-activatable ERBB2 . 189
ESC_J1_UP_EARLY.V1_DNGenes down-regulated during early stages of differentiation of embryoid bodies from J1 embryonic stem cells. 168
ESC_J1_UP_EARLY.V1_UPGenes up-regulated during early stages of differentiation of embryoid bodies from J1 embryonic stem cells. 177
ESC_J1_UP_LATE.V1_DNGenes down-regulated during late stages of differentiation of embryoid bodies from J1 embryonic stem cells. 166
ESC_J1_UP_LATE.V1_UPGenes up-regulated during late stages of differentiation of embryoid bodies from J1 embryonic stem cells. 185
ESC_V6.5_UP_EARLY.V1_DNGenes down-regulated during early stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. 159
ESC_V6.5_UP_EARLY.V1_UPGenes up-regulated during early stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. 162
ESC_V6.5_UP_LATE.V1_DNGenes down-regulated during late stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. 177
ESC_V6.5_UP_LATE.V1_UPGenes up-regulated during late stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. 183
GCNP_SHH_UP_EARLY.V1_DNGenes down-regulated in granule cell neuron precursors (GCNPs) after stimulation with Shh for 3h. 167
GCNP_SHH_UP_EARLY.V1_UPGenes up-regulated in granule cell neuron precursors (GCNPs) after stimulation with Shh for 3h. 173
GCNP_SHH_UP_LATE.V1_DNGenes down-regulated in granule cell neuron precursors (GCNPs) after stimulation with Shh for 24h. 178
GCNP_SHH_UP_LATE.V1_UPGenes up-regulated in granule cell neuron precursors (GCNPs) after stimulation with Shh for 24h. 179
GLI1_UP.V1_DNGenes down-regulated in RK3E cells (kidney epithelium) over-expressing GLI1 . 17
GLI1_UP.V1_UPGenes up-regulated in RK3E cells (kidney epithelium) over-expressing GLI1 . 24
HINATA_NFKB_IMMU_INFImmune or inflammatory genes induced by NF-kappaB in primary keratinocytes and fibroblasts. 15
HINATA_NFKB_MATRIXMatrix, adhesion or cytoskeleton genes induced by NF-kappaB in primary keratinocytes and fibroblasts. 11
HOXA9_DN.V1_DNGenes down-regulated in MOLM-14 cells (AML) with knockdown of HOXA9 gene by RNAi vs controls. 188
HOXA9_DN.V1_UPGenes up-regulated in MOLM-14 cells (AML) with knockdown of HOXA9 gene by RNAi vs controls. 189
IL15_UP.V1_DNGenes down-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 and then stimulated with IL15 . 179
IL15_UP.V1_UPGenes up-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 and then stimulated with IL15 . 187
IL21_UP.V1_DNGenes down-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 and then stimulated with IL21 . 185
IL21_UP.V1_UPGenes up-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 and then stimulated with IL21 . 185
IL2_UP.V1_DNGenes down-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 and then stimulated with IL2 . 188
IL2_UP.V1_UPGenes up-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 and then stimulated with IL2 . 187
JAK2_DN.V1_DNGenes down-regulated in HEL cells (erythroleukemia) after knockdown of JAK2 gene by RNAi. 145
JAK2_DN.V1_UPGenes up-regulated in HEL cells (erythroleukemia) after knockdown of JAK2 gene by RNAi. 179
JNK_DN.V1_DNGenes down-regulated in JNK inhibitor-treated (SP600125) keratinocytes. 189
JNK_DN.V1_UPGenes up-regulated in JNK inhibitor-treated (SP600125) keratinocytes. 185
KRAS.300_UP.V1_DNGenes down-regulated in four lineages of epithelial cell lines over-expressing an oncogenic form of KRAS gene. 140
KRAS.300_UP.V1_UPGenes up-regulated in four lineages of epithelial cell lines over-expressing an oncogenic form of KRAS gene. 141
KRAS.600.LUNG.BREAST_UP.V1_DNGenes down-regulated in epithelial lung and breast cancer cell lines over-expressing an oncogenic form of KRAS gene. 280
KRAS.600.LUNG.BREAST_UP.V1_UPGenes up-regulated in epithelial lung and breast cancer cell lines over-expressing an oncogenic form of KRAS gene. 277
KRAS.AMP.LUNG_UP.V1_DNGenes down-regulated in epithelial lung cancer cell lines over-expressing KRAS gene. 141
KRAS.AMP.LUNG_UP.V1_UPGenes up-regulated in epithelial lung cancer cell lines over-expressing KRAS gene. 139
KRAS.BREAST_UP.V1_DNGenes down-regulated in epithelial breast cancer cell lines over-expressing an oncogenic form of KRAS gene. 142
KRAS.BREAST_UP.V1_UPGenes up-regulated in epithelial breast cancer cell lines over-expressing an oncogenic form of KRAS gene. 139
KRAS.DF.V1_DNGenes down-regulated in epithelial lung cancer cell lines over-expressing an oncogenic form of KRAS gene. 191
KRAS.DF.V1_UPGenes up-regulated in epithelial lung cancer cell lines over-expressing an oncogenic form of KRAS gene. 190
KRAS.KIDNEY_UP.V1_DNGenes down-regulated in epithelial kidney cancer cell lines over-expressing an oncogenic form of KRAS gene. 134
KRAS.KIDNEY_UP.V1_UPGenes up-regulated in epithelial kidney cancer cell lines over-expressing an oncogenic form of KRAS gene. 139
KRAS.LUNG.BREAST_UP.V1_DNGenes down-regulated in epithelial breast cancer cell lines over-expressing an oncogenic form of KRAS . 140
KRAS.PROSTATE_UP.V1_DNGenes down-regulated in epithelial prostate cancer cell lines over-expressing an oncogenic form of KRAS gene. 138
KRAS.PROSTATE_UP.V1_UPGenes up-regulated in epithelial prostate cancer cell lines over-expressing an oncogenic form of KRAS gene. 135
LEF1_UP.V1_DNGenes down-regulated in DLD1 cells (colon carcinoma) over-expressing LEF1 . 185
LEF1_UP.V1_UPGenes up-regulated in DLD1 cells (colon carcinoma) over-expressing LEF1 . 193
LTE2_UP.V1_DNGenes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 MCF-7 cells (breast cancer) and long-term adapted for estrogen-independent growth. 194
LTE2_UP.V1_UPGenes up-regulated in MCF-7 cells (breast cancer) positive for ESR1 MCF-7 cells (breast cancer) and long-term adapted for estrogen-independent growth. 187
MEK_UP.V1_DNGenes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 MCF-7 cells (breast cancer) stably over-expressing constitutively active MAP2K1 gene. 192
MEK_UP.V1_UPGenes up-regulated in MCF-7 cells (breast cancer) positive for ESR1 MCF-7 cells (breast cancer) stably over-expressing constitutively active MAP2K1 gene. 194
MEL18_DN.V1_DNGenes down-regulated in DAOY cells (medulloblastoma) upon knockdown of PCGF2 gene by RNAi. 147
MEL18_DN.V1_UPGenes up-regulated in DAOY cells (medulloblastoma) upon knockdown of PCGF2 gene by RNAi. 141
MTOR_UP.N4.V1_DNGenes down-regulated in CEM-C1 cells (T-CLL) in comparison of control vs rapamycin (sirolimus) , an mTOR pathway inhibitor. 180
MTOR_UP.N4.V1_UPGenes up-regulated in CEM-C1 cells (T-CLL) in comparison of control vs rapamycin (sirolimus) , an mTOR pathway inhibitor. 194
MTOR_UP.V1_DNGenes down-regulated by everolimus in prostate tissue. 182
MTOR_UP.V1_UPGenes up-regulated by everolimus in prostate tissue. 170
MYC_UP.V1_DNGenes down-regulated in primary epithelial breast cancer cell culture over-expressing MYC gene. 165
MYC_UP.V1_UPGenes up-regulated in primary epithelial breast cancer cell culture over-expressing MYC gene. 178
NFE2L2.V2Genes down-regulated in MEF cells (embryonic fibroblasts) after knockout of NFE2L2 gene. 461
NOTCH_DN.V1_DNGenes down-regulated in MOLT4 cells (T-ALL) by DAPT , an inhibitor of NOTCH signaling pathway. 183
NOTCH_DN.V1_UPGenes up-regulated in MOLT4 cells (T-ALL) by DAPT , an inhibitor of NOTCH signaling pathway. 185
NRL_DN.V1_DNGenes down-regulated in retina cells from NRL knockout mice. 130
NRL_DN.V1_UPGenes up-regulated in retina cells from NRL knockout mice. 136
P53_DN.V1_DNGenes down-regulated in NCI-60 panel of cell lines with mutated TP53 . 192
P53_DN.V1_UPGenes up-regulated in NCI-60 panel of cell lines with mutated TP53 . 194
P53_DN.V2_DNGenes down-regulated in HEK293 cells (kidney fibroblasts) upon knockdown of TP53 gene by RNAi. 144
P53_DN.V2_UPGenes up-regulated in HEK293 cells (kidney fibroblasts) upon knockdown of TP53 gene by RNAi. 148
PDGF_ERK_DN.V1_DNGenes down-regulated in SH-SY5Y cells (neuroblastoma) in response to PDGF stimulation after pre-treatment with the ERK inhibitors U0126 and PD98059 . 146
PDGF_ERK_DN.V1_UPGenes up-regulated in SH-SY5Y cells (neuroblastoma) in response to PDGF stimulation after pre-treatment with the ERK inhibitors U0126 and PD98059 . 145
PDGF_UP.V1_DNGenes down-regulated in SH-SY5Y cells (neuroblastoma) in response to PDGF stimulation. 133
PDGF_UP.V1_UPGenes up-regulated in SH-SY5Y cells (neuroblastoma) in response to PDGF stimulation. 145
PGF_UP.V1_DNGenes down-regulated in HUVEC cells (endothelium) by treatment with PGF . 188
PGF_UP.V1_UPGenes up-regulated in HUVEC cells (endothelium) by treatment with PGF . 189
PKCA_DN.V1_DNGenes down-regulated in small intenstine in PRKCA knockout mice. 154
PKCA_DN.V1_UPGenes up-regulated in small intenstine in PRKCA knockout mice. 158
PRC1_BMI_UP.V1_DNGenes down-regulated in TIG3 cells (fibroblasts) upon knockdown of BMI1 gene. 186
PRC1_BMI_UP.V1_UPGenes up-regulated in TIG3 cells (fibroblasts) upon knockdown of BMI1 gene. 184
PRC2_EED_DN.V1_DNGenes down-regulated in TIG3 cells (fibroblasts) upon knockdown of EED gene. 191
PRC2_EED_DN.V1_UPGenes up-regulated in TIG3 cells (fibroblasts) upon knockdown of EED gene. 190
PRC2_EZH2_UP.V1_DNGenes down-regulated in TIG3 cells (fibroblasts) upon knockdown of EZH2 gene. 190
PRC2_EZH2_UP.V1_UPGenes up-regulated in TIG3 cells (fibroblasts) upon knockdown of EZH2 gene. 190
PRC2_SUZ12_UP.V1_DNGenes down-regulated in TIG3 cells (fibroblasts) upon knockdown of SUZ12 gene. 189
PRC2_SUZ12_UP.V1_UPGenes up-regulated in TIG3 cells (fibroblasts) upon knockdown of SUZ12 gene. 184
PTEN_DN.V1_DNGenes down-regulated upon knockdown of PTEN by RNAi. 184
PTEN_DN.V1_UPGenes up-regulated upon knockdown of PTEN by RNAi. 186
PTEN_DN.V2_DNGenes down-regulated in HCT116 cells (colon carcinoma) upon knockdown of PTEN by RNAi. 143
PTEN_DN.V2_UPGenes up-regulated in HCT116 cells (colon carcinoma) upon knockdown of PTEN by RNAi. 138
RAF_UP.V1_DNGenes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 MCF-7 cells (breast cancer) stably over-expressing constitutively active RAF1 gene. 193
RAF_UP.V1_UPGenes up-regulated in MCF-7 cells (breast cancer) positive for ESR1 MCF-7 cells (breast cancer) stably over-expressing constitutively active RAF1 gene. 193
RAPA_EARLY_UP.V1_DNGenes down-regulated in BJAB (lymphoma) cells by rapamycin (sirolimus) . 184
RAPA_EARLY_UP.V1_UPGenes up-regulated in BJAB (lymphoma) cells by rapamycin (sirolimus) . 166
RB_DN.V1_DNGenes down-regulated in primary keratinocytes from RB1 skin specific knockout mice. 121
RB_DN.V1_UPGenes up-regulated in primary keratinocytes from RB1 skin specific knockout mice. 116
RB_P107_DN.V1_DNGenes down-regulated in primary keratinocytes from RB1 and RBL1 skin specific knockout mice. 125
RB_P107_DN.V1_UPGenes up-regulated in primary keratinocytes from RB1 and RBL1 skin specific knockout mice. 130
RB_P130_DN.V1_DNGenes down-regulated in primary keratinocytes from RB1 and RBL2 skin specific knockout mice. 132
RB_P130_DN.V1_UPGenes up-regulated in primary keratinocytes from RB1 and RBL2 skin specific knockout mice. 130
RELA_DN.V1_DNGenes down-regulated in HEK293 cells (kidney fibroblasts) upon knockdown of RELA gene by RNAi. 139
RELA_DN.V1_UPGenes up-regulated in HEK293 cells (kidney fibroblasts) upon knockdown of RELA gene by RNAi. 149
RPS14_DN.V1_DNGenes down-regulated in CD34+ hematopoietic progenitor cells after knockdown of RPS14 by RNAi. 185
RPS14_DN.V1_UPGenes up-regulated in CD34+ hematopoietic progenitor cells after knockdown of RPS14 by RNAi. 190
SINGH_KRAS_DEPENDENCY_SIGNATUREGenes defining the KRAS dependency signature. 20
SIRNA_EIF4GI_DNGenes down-regulated in MCF10A cells vs knockdown of EIF4G1 gene by RNAi. 97
SIRNA_EIF4GI_UPGenes up-regulated in MCF10A cells vs knockdown of EIF4G1 gene by RNAi. 95
SNF5_DN.V1_DNGenes down-regulated in MEF cells (embryonic fibroblasts) with knockout of SNF5 gene. 156
SNF5_DN.V1_UPGenes up-regulated in MEF cells (embryonic fibroblasts) with knockout of SNF5 gene. 172
SRC_UP.V1_DNGenes down-regulated in primary epithelial breast cancer cell culture over-expressing SRC gene. 166
SRC_UP.V1_UPGenes up-regulated in primary epithelial breast cancer cell culture over-expressing SRC gene. 175
STK33_DNGenes down-regulated in NOMO-1 and SKM-1 cells (AML) after knockdown of STK33 by RNAi. 278
STK33_NOMO_DNGenes down-regulated in NOMO-1 cells (AML) after knockdown of STK33 by RNAi. 278
STK33_NOMO_UPGenes up-regulated in NOMO-1 cells (AML) after knockdown of STK33 by RNAi. 287
STK33_SKM_DNGenes down-regulated in SKM-1 cells (AML) after knockdown of STK33 by RNAi. 275
STK33_SKM_UPGenes up-regulated in SKM-1 cells (AML) after knockdown of STK33 by RNAi. 271
STK33_UPGenes up-regulated in NOMO-1 and SKM-1 cells (AML) after knockdown of STK33 by RNAi. 282
TBK1.DF_DNGenes down-regulated in epithelial lung cancer cell lines upon over-expression of an oncogenic form of KRAS gene and knockdown of TBK1 gene by RNAi. 286
TBK1.DF_UPGenes up-regulated in epithelial lung cancer cell lines upon over-expression of an oncogenic form of KRAS gene and knockdown of TBK1 gene by RNAi. 284
TGFB_UP.V1_DNGenes down-regulated in a panel of epithelial cell lines by TGFB1 . 187
TGFB_UP.V1_UPGenes up-regulated in a panel of epithelial cell lines by TGFB1 . 188
VEGF_A_UP.V1_DNGenes down-regulated in HUVEC cells (endothelium) by treatment with VEGFA . 192
VEGF_A_UP.V1_UPGenes up-regulated in HUVEC cells (endothelium) by treatment with VEGFA . 193
WNT_UP.V1_DNGenes down-regulated in C57MG cells (mammary epithelium) by over-expression of WNT1 gene. 170
WNT_UP.V1_UPGenes up-regulated in C57MG cells (mammary epithelium) by over-expression of WNT1 gene. 175
YAP1_DNGenes down-regulated in MCF10A cells (breast cancer) over-expressing YAP1 gene. 45
YAP1_UPGenes up-regulated in MCF10A cells (breast cancer) over-expressing YAP1 gene. 45