Hallmark gene sets (50)

Gene set Name Definition Number of genes
HALLMARK_ADIPOGENESISGenes up-regulated during adipocyte differentiation (adipogenesis). 200
HALLMARK_ALLOGRAFT_REJECTIONGenes up-regulated during transplant rejection. 200
HALLMARK_ANDROGEN_RESPONSEGenes defining response to androgens. 100
HALLMARK_ANGIOGENESISGenes up-regulated during formation of blood vessels (angiogenesis). 36
HALLMARK_APICAL_JUNCTIONGenes encoding components of apical junction complex. 198
HALLMARK_APICAL_SURFACEGenes encoding proteins over-represented on the apical surface of epithelial cells, e.g., important for cell polarity (apical area). 44
HALLMARK_APOPTOSISGenes mediating programmed cell death (apoptosis) by activation of caspases. 161
HALLMARK_BILE_ACID_METABOLISMGenes involve in metabolism of bile acids and salts. 112
HALLMARK_CHOLESTEROL_HOMEOSTASISGenes involved in cholesterol homeostasis. 74
HALLMARK_COAGULATIONGenes encoding components of blood coagulation system; also up-regulated in platelets. 138
HALLMARK_COMPLEMENTGenes encoding components of the complement system, which is part of the innate immune system. 200
HALLMARK_DNA_REPAIRGenes involved in DNA repair. 150
HALLMARK_E2F_TARGETSGenes encoding cell cycle related targets of E2F transcription factors. 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONGenes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. 200
HALLMARK_ESTROGEN_RESPONSE_EARLYGenes defining early response to estrogen. 198
HALLMARK_ESTROGEN_RESPONSE_LATEGenes defining late response to estrogen. 198
HALLMARK_FATTY_ACID_METABOLISMGenes encoding proteins involved in metabolism of fatty acids. 157
HALLMARK_G2M_CHECKPOINTGenes involved in the G2/M checkpoint, as in progression through the cell division cycle. 199
HALLMARK_GLYCOLYSISGenes encoding proteins involved in glycolysis and gluconeogenesis. 200
HALLMARK_HEDGEHOG_SIGNALINGGenes up-regulated by activation of hedgehog signaling. 36
HALLMARK_HEME_METABOLISMGenes involved in metabolism of heme (a cofactor consisting of iron and porphyrin) and erythroblast differentiation. 200
HALLMARK_HYPOXIAGenes up-regulated in response to low oxygen levels (hypoxia). 200
HALLMARK_IL2_STAT5_SIGNALINGGenes up-regulated by STAT5 in response to IL2 stimulation. 198
HALLMARK_IL6_JAK_STAT3_SIGNALINGGenes up-regulated by IL6 via STAT3 , e.g., during acute phase response. 87
HALLMARK_INFLAMMATORY_RESPONSEGenes defining inflammatory response. 200
HALLMARK_INTERFERON_ALPHA_RESPONSEGenes up-regulated in response to alpha interferon proteins. 97
HALLMARK_INTERFERON_GAMMA_RESPONSEGenes up-regulated in response to IFNG . 198
HALLMARK_KRAS_SIGNALING_DNGenes down-regulated by KRAS activation. 200
HALLMARK_KRAS_SIGNALING_UPGenes up-regulated by KRAS activation. 200
HALLMARK_MITOTIC_SPINDLEGenes important for mitotic spindle assembly. 199
HALLMARK_MTORC1_SIGNALINGGenes up-regulated through activation of mTORC1 complex. 199
HALLMARK_MYC_TARGETS_V1A subgroup of genes regulated by MYC - version 1 (v1). 199
HALLMARK_MYC_TARGETS_V2A subgroup of genes regulated by MYC - version 2 (v2). 57
HALLMARK_MYOGENESISGenes involved in development of skeletal muscle (myogenesis). 199
HALLMARK_NOTCH_SIGNALINGGenes up-regulated by activation of Notch signaling. 32
HALLMARK_OXIDATIVE_PHOSPHORYLATIONGenes encoding proteins involved in oxidative phosphorylation. 200
HALLMARK_P53_PATHWAYGenes involved in p53 pathways and networks. 199
HALLMARK_PANCREAS_BETA_CELLSGenes specifically up-regulated in pancreatic beta cells. 40
HALLMARK_PEROXISOMEGenes encoding components of peroxisome. 104
HALLMARK_PI3K_AKT_MTOR_SIGNALINGGenes up-regulated by activation of the PI3K/AKT/mTOR pathway. 105
HALLMARK_PROTEIN_SECRETIONGenes involved in protein secretion pathway. 96
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYGenes up-regulated by reactive oxigen species (ROS). 49
HALLMARK_SPERMATOGENESISGenes up-regulated during production of male gametes (sperm), as in spermatogenesis. 134
HALLMARK_TGF_BETA_SIGNALINGGenes up-regulated in response to TGFB1 . 54
HALLMARK_TNFA_SIGNALING_VIA_NFKBGenes regulated by NF-kB in response to TNF . 199
HALLMARK_UNFOLDED_PROTEIN_RESPONSEGenes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum. 112
HALLMARK_UV_RESPONSE_DNGenes down-regulated in response to ultraviolet (UV) radiation. 144
HALLMARK_UV_RESPONSE_UPGenes up-regulated in response to ultraviolet (UV) radiation. 158
HALLMARK_WNT_BETA_CATENIN_SIGNALINGGenes up-regulated by activation of WNT signaling through accumulation of beta catenin CTNNB1 . 42
HALLMARK_XENOBIOTIC_METABOLISMGenes encoding proteins involved in processing of drugs and other xenobiotics. 199