Synthetic lethal gene pairs


Data mining workflows are available for evaluating the synthetic lethality of gene pairs

1) CRISPR (shRNA) efficacy of gene A are associated with mRNA expression of gene B, vice versa

Left panel) CRISPR efficacy of RNF113A is negatively associated with RNA expression of NKAP

Right panel) CRISPR efficacy of NKAP is negatively associated with RNA expression of RNF113A

2) Low expression of both gene A & B are favorable to patient survival